Objective To investigate the effect of the information-motivation-behavioral skills (IMB) intervention model on secondary osteoporosis in postmenopausal breast cancer patients treated with aromatase inhibitor (AI).Methods Seventy-six postmenopausal breast cancer patients with secondary osteoporosis undergoing AI treatment were enrolled and randomly divided into a control group (37 cases) and an observation group (39 cases) using a random number table. The control group received routine management, while the observation group received additional IMB-based interventions. Physical function was assessed using the Short Physical Performance Battery (SPPB). Bone mineral density (BMD) at the femoral neck and lumbar spine (L1-L4) was measured via dual-energy X-ray absorptiometry. Serum calcium, phosphorus, and other bone metabolism indicators were analyzed using an automated biochemical analyzer. Quality of life was evaluated with the Chinese Osteoporosis Quality of Life Scale (COQOL), and nursing satisfaction was assessed.Results At 6 and 12 weeks post-intervention, the observation group showed significantly higher SPPB scores (gait speed, chair stand, and balance function), elevated serum calcium and phosphorus levels (P<0.05), and lower COQOL scores (indicating improved quality of life) compared to the control group (P<0.05). At 6 weeks, lumbar (L1-L4) and femoral neck BMD in the observation group exhibited an upward trend but without statistical significance (P>0.05); by 12 weeks, these BMD values were significantly higher than those in the control group (P<0.05). Nursing satisfaction in the observation group (97.44%) was significantly higher than in the control group (81.08%) (P<0.05).Conclusion The IMB intervention model effectively improves physical function, slows the decline in bone metabolism indicators and BMD, enhances quality of life, and alleviates osteoporosis symptoms in postmenopausal breast cancer patients with secondary osteoporosis receiving AI therapy.