铂类药物溶媒要求差异性原因分析

doi:10.3969/j.issn.2095-1264.2025.02.08

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铂类药物溶媒要求差异性原因分析
DOI:
                        10.3969/j.issn.2095-1264.2025.02.08
                    
作者:
                        
                        
                    
作者单位:1.贵航贵阳医院药剂科，贵州 贵阳，550009;2.长寿区中医院检验科，重庆，401220;3.重庆医科大学附属儿童医院儿研所，重庆，400010
作者简介:刘馨，女，主管药师，研究方向为医院药学。
通讯作者:夏雷，男，博士，主管药师，研究方向为药理学。
中图分类号:R730;R979.1;R94
基金项目:

Analysis of the causes for variation in solvent selection of platinum-based drugs

Author:

Affiliation:

1.Pharmacy Department, Guihang Guiyang Hospital, Guiyang, 550009, Guizhou, China;2.Department of Clinical Laboratory, Changshou District Hospital of Traditional Chinese Medicine, Chongqing, 401220, China;3.Institute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, 400010, China

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摘要:

铂类药物的化学稳定性是影响其溶媒选择的关键因素，主要取决于其配位化学结构稳定性。铂类药物稳定性顺序为：洛铂、奥沙利铂>卡铂、奈达铂>顺铂。顺铂和奈达铂因结构不稳定，适合使用0.9% 氯化钠注射液作为溶媒；而卡铂、洛铂和奥沙利铂结构稳定，更适合采用5%葡萄糖注射液作为溶媒。

Abstract:

The chemical stability of platinum-based drugs is a critical factor influencing the selection of solvent media, primarily determined by the stability of their coordination chemistry structures. The stability order of platinum-based drugs is as follows: lobaplatin, oxaliplatin > carboplatin, nedaplatin > cisplatin. Cisplatin and nedaplatin, due to their structural instability, are suitable for use with 0.9% sodium chloride injection as the solvent medium. In contrast, carboplatin, lobaplatin, and oxaliplatin, which are structurally stable, are more appropriately administered with 5% glucose injection as the solvent medium.