Objective To develop an expert consensus on the standardization of pain management in cancer pain-free wards (hereinafter referred to as the "Consensus"), in order to guide healthcare professionals in implementing standardized, comprehensive safety management of cancer pain throughout the pain management process, enhance clinical competency in pain management, and improve the quality of life for cancer patients.Methods The Consensus was formulated using evidence-based medicine methods, including systematic evidence retrieval, critical appraisal, and integration of recommendations graded by evidence quality. The development process involved expert consultations and three rounds of multidisciplinary panel discussions (June to November 2024), followed by revision and finalization. The protocol was registered on the International Practice Guideline Registration Platform (Registration ID: PREPARE-2025CN088).Results The Consensus delineates core components for pain-free ward management, encompassing definitions, scope of application, operational principles, institutional frameworks, multidisciplinary team coordination, objectives, and evidence-based implementation strategies (e.g., pain assessment protocols, analgesic interventions, pain-specific nursing care, patient and caregiver education, follow-up mechanisms, quality control, and outcome evaluation).Conclusion This Consensus demonstrates scientific rigor and practical applicability, providing a standardized reference framework for establishing and optimizing pain-free wards in oncology clinical settings.