伊布替尼治疗慢性淋巴细胞白血病引起急性肾损伤不良反应1例

doi:10.3969/j.issn.2095-1264.2024.01.07

首页 > 过刊浏览>2024年第1期 >40-44. DOI:10.3969/j.issn.2095-1264.2024.01.07

伊布替尼治疗慢性淋巴细胞白血病引起急性肾损伤不良反应1例
DOI:
                        10.3969/j.issn.2095-1264.2024.01.07
                    
作者:
                        
                        
                    
作者单位:1.山西省肿瘤医院/中国医学科学院肿瘤医院山西医院/山西医科大学附属肿瘤医院 药学部，山西 太原，030013;2.山西医科大学药学院，山西 太原，030001;3.山西医科大学第二医院 药学部，山西 太原，030001
作者简介:任志宏，男，主管药师，研究方向：抗肿瘤药物合理使用。
通讯作者:尹冬虹，女，硕士，副主任药师，研究方向：临床药学。
中图分类号:R733.7;R969.3
基金项目:

A case of acute kidney injury adverse reaction caused by ibrutinib in the treatment of chronic lymphocytic leukemia

Author:

Affiliation:

1.Department of Pharmacy, Shanxi Cancer Hospital/Shanxi Hospital, Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030013, Shanxi, China;2.School of Pharmacy, Shanxi Medical University, Taiyuan, 030001, Shanxi, China;3.Department of Pharmacy, the Second Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China

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摘要:

目的探讨伊布替尼致急性肾损伤的临床特征和处置措施。方法以1例伊布替尼治疗慢性淋巴细胞白血病引起急性肾损伤不良反应为切入点，检索FAERS数据库和查阅文献，分析其临床特征和处置措施。结果数据显示，伊布替尼引起急性肾损伤的发生率很低，表现为血清肌酐水平升高，可合并蛋白尿、血尿，肾活检显示为急性间质性肾炎或急性肾小管坏死。及时停药、经糖皮质激素等免疫抑制治疗后，部分患者血清肌酐水平可有所恢复。结论临床医生应权衡利弊，密切监测患者血肌酐，保障患者用药安全。

Abstract:

Objective To explore the clinical features and management of ibrutinib-induced acute kidney injury.Methods Taking a case of ibrutinib-induced acute kidney injury in chronic lymphocytic leukemia as an entry point, the clinical characteristics and treatment measures were analyzed by searching the FAERS database and reviewing the literature.Results The data showed a low incidence of acute renal injury caused by ibrutinib, which was characterized by increased serum creatinine, proteinuria, hematuria, acute interstitial nephritis or acute tubular necrosis. The serum creatinine of some patients can be recovered after timely withdrawal of the drug and immunosuppressive therapy such as glucocorticoid.Conclusion Clinicians should weigh the pros and cons and closely monitor the serum creatinine of patients to ensure the safety of medication.