基于数据挖掘的中药防治肿瘤治疗所致皮肤损伤的用药分析

doi:10.3969/j.issn.2095-1264.2022.02.17

首页 > 过刊浏览>2022年第2期 >244-251. DOI:10.3969/j.issn.2095-1264.2022.02.17

基于数据挖掘的中药防治肿瘤治疗所致皮肤损伤的用药分析
DOI:
                        10.3969/j.issn.2095-1264.2022.02.17
                    
作者:
                        
                        
                    
作者单位:1.海阳市人民医院，山东 海阳，265100;2.中日友好医院，北京，100029;3.首都儿科研究所附属儿童医院， 北京，100020;4.北京中医药大学附属东方医院，北京，100078;5.青岛市中心医院，山东 青岛，266042
作者简介:段为彬，男，硕士，主管中药师，研究方向：中药临床研究。
通讯作者:柳芳，女，博士，中药临床药师，研究方向：中药安全性研究。
中图分类号:R28
基金项目:

Data mining-based analysis of traditional Chinese medicine in preventing and treating skin lesion caused by oncotherapy

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Affiliation:

1.Haiyang People's Hospital, Haiyang, Shandong, 265100, China;2.China-Japan Friendship Hospital, Beijing, 100029, China;3.Children's Hospital Affiliated to the Capital Institute of Pediatrics, Beijing, 100020, China;4.Dongfang Hospital Beijing University of Chinese Medicine, Beijing, 100078, China;5.Qingdao Central Hospital, Qingdao, Shandong, 266042, China

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摘要:

目的分析中药防治肿瘤相关治疗所致皮肤损伤的用药规律，以指导临床用药。方法检索中国知网、万方数据库，筛选中药防治肿瘤相关治疗所致皮肤损伤的临床研究，对外用、内服中药分别从使用频次、功效、药性、药味、归经等方面进行统计，对使用频次较高的中药进行聚类分析和关联分析。结果共纳入文献115篇，涉及方剂120首。其中，外用方剂94首，涉及中药154味，使用频次较高的为黄柏、当归、红花、黄芪、紫草；内服方剂26首，涉及中药113味，使用频次较高的为当归、甘草。外用中药中，清热药所占比例最大（33.24%）；内服中药中，补虚药所占比例最大（32.78%）。外用和内服中药中，使用频次均以寒性者最多，分别占47.52%和40.73%；以归肝经者最多，分别占21.29%和19.27%。外用中药使用频率较高的药味依次为苦、辛、甘，三者共占89.74%，内服中药使用频率较高的药味依次为甘、苦、辛，三者共占90.82%。外用和内服中药均可得到三个聚类方，外用中药得到23对药物组合，内服中药得到15对药物组合。结论临床使用中药防治肿瘤相关治疗所致皮肤损伤时，外用、内服中药均以清热药、补虚药、活血化瘀药和解表药为主。对使用频次较高的中药进行聚类分析和关联分析，可为临床用药选择提供参考。

Abstract:

Objective To explore the regularities of traditional Chinese medicine (TCM) in preventing and treating the skin lesion caused by anti-tumor therapies, in order to guide clinical medication.Methods The clinical research articles on TCM in the prevention and treatment of skin lesion caused by anti-tumor therapies were retrieved from the China National Knowledge Infrastructure and Wanfang Database. The frequency of use, efficacy, property, flavour, and meridian tropism of different medicinal herbs were calculated and analyzed. Cluster analysis and association analysis were carried out for medicinal herbs with high frequency.Results In total, 115 literatures were included in this study, involving 120 prescriptions, 94 for external use and 26 for internal use. In the 94 prescriptions for external use, involved were 154 medicinal herbs, among which Huangbai, Danggui, Honghua, Huangqi, and Zicao were the most frequently used. In the 26 prescriptions for internal use, involved were 113 medicinal herbs, among which Danggui and Gancao were the most frequently used. Among the medicinal herbs for external use, heat-clearing herbs were the most frequently used (33.24%), while deficiency-tonifying herbs were the most frequently used (32.78%) among those for internal use. The medicinal herbs cold in property were the most frequently used in both external-use and internal-use prescriptions (respectively 47.52% and 40.73%). As for flavour, the most frequently used herbs for external use in turn were bitter, pungent, sweet, with a total frequency of 89.74%; while the most frequently used herbs for internal use in turn were sweet, bitter, pungent, with a total frequency of 90.82%. The meridian tropism of the herbs mainly focused on liver in both external-use and internal-use prescriptions (respectively 21.29% and 19.27%). For external-use herbs, there were three clusters, including 23 pairs of high-frequency drug combinations. For internal-use herbs, there were also three clusters, including 15 pairs of high-frequency drug combinations.Conclusion In the prevention and treatment of skin lesion which was caused by anti-tumor therapies, both external-use and internal-use TCM were focused on heat-clearing, deficiency-tonifying, blood-invigorating and blood stasis-dispelling, and relieving drugs. The results of cluster analysis and association analysis of high frequency TCM can provide certain reference and guidance for clinical medication.