紫贝止咳颗粒治疗肺癌根治术后咳嗽70例临床观察

doi:10.3969/j.issn.2095-1264.2022.02.15

首页 > 过刊浏览>2022年第2期 >234-237. DOI:10.3969/j.issn.2095-1264.2022.02.15

紫贝止咳颗粒治疗肺癌根治术后咳嗽70例临床观察
DOI:
                        10.3969/j.issn.2095-1264.2022.02.15
                    
作者:
                        
                        
                    
作者单位:湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院 胸外二科，湖南 长沙，410013
作者简介:苏敏，男，博士，助理研究员，研究方向：肺癌和食管癌基础与转化研究。
通讯作者:王文祥，男，博士，主任医师，研究方向：胸部肿瘤规范化诊治。
中图分类号:R734.2;R730.6
基金项目:

Clinical observation of Zibei Zhike granules on 70 cases of lung cancer patients with cough after radical resection

Author:

Affiliation:

The Second Department of Thoracic Surgery, Hunan Cancer Hospital / the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China

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摘要:

目的评价紫贝止咳颗粒治疗肺癌根治术后咳嗽的临床疗效。方法采取随机对照方法，将140例符合纳入标准的肺癌根治术后咳嗽患者按1∶1的比例随机分为两组，对照组给予氨酚双氢可待因片口服治疗，治疗组给予紫贝止咳颗粒口服治疗，对两组患者进行治疗前后咳嗽评分并评价疗效。结果两组治疗后咳嗽症状评分均低于治疗前，差异具有统计学意义（P<0.05）。对照组治疗总有效率为87.14%，治疗组为84.28%，两组间差异无统计学意义（P>0.05）。治疗后，两组患者生活质量评分（包括LCQ总评分、生理评分、心理评分和社会评分）比较，差异均无统计学意义（P>0.05）。结论紫贝止咳颗粒对肺癌根治术后咳嗽患者具有良好的临床疗效和安全性。

Abstract:

Objective To evaluate the clinical efficacy of Zibei Zhike granules in the treatment of cough after radical resection of lung cancer.Methods A randomized, parallel controlled clinical study was conducted. A total of 140 lung cancer patients with cough after radical resection were randomly divided into two groups in a ratio of 1∶1. Patients in control group were treated with codeine phosphate tablets, and those in treatment group were given Zibei Zhike granules. The cough scores of the two groups before and after treatment were observed and the efficacy was evaluated.Results The cough symptom score in the two groups after treatment was lower than before treatment, and the difference was statistically significant (P<0.05). After treatment, the total effective rate was 87.14% in the control group, and 84.28% in the treatment group, with no statistical significance between the two groups (P>0.05). Yet, no significant difference was observed in quality of life scores between the two groups, including LCQ total score, physiological score, psychological score and social score (P>0.05).Conclusion Zibei Zhike granules had good clinical efficacy and safety in the treatment of cough after radical resection of lung cancer.