Objective To study the effects of tumor patient-specific enteral nutritional emulsion on the nutritional status and immune function of tumor patients with chemotherapy.Methods A total of 84 tumor patients who received chemotherapy in our hospital between March 2016 and March 2018 were selected in the study. They were divided into observation group and control group according to different nutritional methods, with 42 patients in each group. All patients were treated with conventional chemotherapy. Patients in control group were treated with conventional nutritional intervention according to their specific nutritional status. And those in observation group were intervened with enteral nutritional emulsion supportive treatment. The differences of nutritional status, immune function and adverse reactions were compared between the two groups before and after chemotherapy.Results After chemotherapy, the levels of serum total protein, prealbumin, transferrin and hemoglobin in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). The CD4⁺ level and the CD4⁺/CD8⁺ in the observation group were higher than in the control group, while the CD8⁺ level was lower than in the control group, with statistical differences (P<0.05). There were no significant differences in the incidence of leukopenia, thrombocytopenia, nausea and vomiting, insomnia and phlebitis between the observation group and the control group (P>0.05).Conclusion Enteral nutrition emulsion can effectively improve the nutritional status and immune function of tumor chemotherapy patients without increasing the risk of adverse reactions. It is safe and worthy of clinical application.