Abstract:The graded management of clinical application of anti-tumor drugs is not only the core strategy of anti-tumor drug management, but also the important and difficult problem of anti-tumor drug management at present. In the light of relevant national policies and management practice in our hospital, here we analyzed and discussed three core problems (formulation of catalogue of graded anti-tumor drugs, conditions for granting permission of anti-tumor drugs prescription in different levels, off-label drug use) in the graded management of anti-tumor drugs. We also made relevant suggestions, hoping to provide reference for the development of graded management of anti-tumor drugs in medical institutions.