Objective To investigate the effects of incision local anesthesia infiltration on the prevention of postoperative hyperalgesia in patients with continuous infusion of remifentanil.Methods A total of 68 patients who underwent open resection of liver tumors in Qinghai Red Cross Hospital between January 2019 and December 2019 were selected as the research subjects. They were divided into two groups by the random number table method, with 34 cases in each group. Observation group: patients got local anesthesia infiltration at the incision when the abdomen was closed after operation. Control group: no anesthesia was done when the abdomen was closed after operation. Record the scores of Bruggrmann comfort scale (BCS) and visual analogue scale (VAS) of patients right after surgery and at 30, 60, 90 min after surgery, as well as the amount of sufentanil, the number of additional analgesia, the occurrence of adverse reactions.Results The BCS score of the observation group was higher than that of the control group at all time points after operation (P<0.05), and the VAS score of the observation group was lower than that of the control group at all time points after operation (P<0.05). Sufentani dosage in the observation group at postoperative 1 h, 1 d, and 2 d was significantly lower than that in the control group respectively, and the number of patients with additional analgesia was less than that in the control group (P<0.05).Conclusion Incision local anesthesia infiltration can prevent postoperative hyperalgesia of patients with remifentanil infusion, and improve the comfort of patients without obvious adverse reactions.