Objective To explore the impact of food on the bioavailability of oral antit-umor drugs.Methods The relevant literatures on the effect of food on the bioavailability of oral anti-tumor drugs in SCI, GeenMedical, PubMed, CNKI and Wanfang databases were searched and sorted out.Results Food can affect the bioavailability of some oral anti-tumor drugs. Drugs that should be taken on an empty stomach include etoposide, temozolomide, sorafenib, ceritinib, and that need to be taken with food include vinorelbine, imatinib, vemurafenib, alectinib. Drugs that should be avoided taken orally with food include uracil tigafur, S-1, capecitabine, lapatinib, erlotinib, pazopanib, afatinib, apatinib, trametinib, dabrafenib, exemestane, and abiraterone.Conclusion Clinical medication should pay attention to the impact of food on the bioavailability of oral anti-tumor drugs. It is necessary to guide patients to use drugs rationally, so as to ensure the effectiveness and safety of anti-tumor drugs.