miRNA在舌鳞状细胞癌化疗耐药中的研究进展

doi:10.3969/j.issn.2095-1264.2025.05.10

首页 > 过刊浏览>2025年第15卷第5期 >647-655. DOI:10.3969/j.issn.2095-1264.2025.05.10

miRNA在舌鳞状细胞癌化疗耐药中的研究进展
DOI:
                        10.3969/j.issn.2095-1264.2025.05.10
                    
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作者单位:1.南华大学衡阳医学院 湖南省肿瘤医院研究生协作培养基地，湖南 衡阳，421001; 湖南省肿瘤医院 2.头颈外科;2.药学部，湖南 长沙，410013
作者简介:张柏城，男，硕士，住院医师，研究方向为头颈外科。
通讯作者:周晓，男，硕士，教授，研究方向为头颈外科。
中图分类号:R739.86
基金项目:国家自然科学基金面上项目（82273466）。

Progress of miRNA in chemoresistance of squamous cell carcinoma of the tongue

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Affiliation:

1.Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China;2.Head and Neck Surgery Department;3.Pharmacy Department, Hunan Cancer Hospital, Changsha, 410013, Hunan, China

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摘要:

舌鳞状细胞癌（TSCC）是口腔鳞状细胞癌中最常见的一种类型，由于其浸润率和转移率高，患者预后较差。临床对TSCC主要采取以手术治疗为主、放化疗为辅的综合治疗方案。目前，化疗仍是TSCC的主要治疗策略之一，而耐药问题是TSCC化疗面临的重要挑战，也是患者复发和预后不良的重要原因。miRNA被认为是人类基因表达调控的关键因子，参与各种生理和病理过程，包括但不限于正常生长发育、肿瘤发生发展及化疗耐药。本文综述了miRNA对TSCC化疗敏感性的重要调控作用，以期为深入了解TSCC化疗耐药分子机制提供有用信息。

Abstract:

Tongue squamous cell carcinoma (TSCC) is the most common type of squamous cell carcinoma among oral tumours, and the prognosis of patients is poor due to its high infiltration rate and high metastasis rate. The treatment plan for TSCC is a combination of surgical treatment, supplemented by radiotherapy and chemotherapy, Chemotherapy remains one of the main therapeutic strategies for the treatment of TSCC, while chemoresistance becomes the main challenge of chemotherapy for TSCC, and the main cause of TSCC recurrence and poor prognosis. MicroRNAs (miRNAs) are considered to be the key regulators of gene expression in human beings. They are involved in a variety of physiological and pathological processes, including but not limited to normal growth and development, tumourigenesis, and chemotherapy resistance. This review summarized the important regulatory roles of miRNAs in the chemosensitivity of TSCC, in order to provide useful information for further understanding the molecular mechanism of chemoresistance of TSCC.