Lung cancer has become the most prevalent malignant tumor among all cancers worldwide in recent years. Currently, clinical treatment is facing a severe challenge of drug resistance, and there is an urgent need to develop new strategies to address this issue. Ferroptosis is a form of iron-dependent non-apoptotic cell death, which mainly involves the impairment of the antioxidant defense function of the system X_c^--GPX4 pathway, the accumulation of lipid peroxidation, and the disorder of intracellular iron metabolism. Studies have shown that inducing ferroptosis can significantly enhance the sensitivity of tumor cells to conventional treatments in multiple lung cancer treatment fields, including radiotherapy, chemotherapy, targeted therapy, and immunotherapy, thereby reversing drug resistance. Currently, some ferroptosis-related drugs and novel delivery systems have entered the clinical trial stage. In addition, the discovery of new natural ferroptosis agonists and the continuous clarification of their target sites have also provided new research directions and strategies for lung cancer treatment.