氟马替尼治疗慢性髓系白血病合并IgG4相关自身免疫性胰腺炎1例病例报道并文献分析

doi:10.3969/j.issn.2095-1264.2025.03.18

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氟马替尼治疗慢性髓系白血病合并IgG4相关自身免疫性胰腺炎1例病例报道并文献分析
DOI:
                        10.3969/j.issn.2095-1264.2025.03.18
                    
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作者单位:1.山西医科大学第二医院，全科医学科，山西 太原，030000;2.山西医科大学第二医院，血液内科，山西 太原，030000
作者简介:范柄汝，女，硕士研究生，研究方向为恶性血液病。
通讯作者:葛晓燕，女，博士，教授，主任医师，硕士生导师，研究方向为恶性血液病。
中图分类号:R733.72;R979.1
基金项目:

A case report and literature review of flumatinib in the treatment of chronic myeloid leukemia combined with IgG4-related autoimmune pancreatitis

Author:

Affiliation:

1.Department of General Practice;2.Hematology Department, Second Hospital of Shanxi Medical University,Taiyuan, 030000, Shanxi, China

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摘要:

本文报道1例接受氟马替尼治疗的慢性髓系白血病（CML）患者并发IgG4相关免疫性胰腺炎的病例。目前酪氨酸激酶抑制剂（TKI）相关急性胰腺炎的发生率较低（多见于尼洛替尼和伊马替尼，氟马替尼仅见1例报道），但尚未见合并IgG4相关免疫性胰腺炎的病例报道。此外，尽管恶性血液病合并IgG4相关疾病已有报道，但CML与IgG4相关疾病之间的关联尚未明确，本病例为此提供了新的临床参考依据。

Abstract:

This study reports a case of IgG4-related autoimmune pancreatitis occurring in a chronic myeloid leukemia (CML) patient during flumatinib treatment. Currently, the incidence of tyrosine kinase inhibitor (TKI)-induced acute pancreatitis remains low (with more cases reported for nilotinib and imatinib, but only one documented case for flumatinib), and no cases of concurrent IgG4-related autoimmune pancreatitis have been reported. Furthermore, although the co-occurrence of hematological malignancies and IgG4-related diseases has been documented, the association between CML and IgG4-related disease remains unclear. This case provides valuable clinical insights into this potential correlation.