Objective To analyze and discuss the drug treatment and pharmaceutical care process of an AIDS patient with breast cancer, in order to provide some reference for the clinical treatment of such special patients.Methods A case of AIDS with breast cancer treated with chemotherapy was analyzed and discussed based on evidence-based medicine in terms of anti-tumor drug dosage optimization, anti-HIV regimen adjustment, prevention of opportunistic infections and so on, and suggestions for the patient's pharmaceutical care program were put forward.Results Based on the results of evidence-based treatment, the patient received effective anti-HIV and anti-tumor therapy, and successfully completed 7 cycles of chemotherapy without significant adverse effects. The patient had remission of the disease.Conclusion The treatment principle of AIDS patients with breast cancer can be the same as that of ordinary tumor patients, and they can be given standard dose of chemotherapy drugs. At the same time, medication monitoring should be done well. Clinical pharmacists can play their professional advantages in the treatment of special patients and embody their value in the multidisciplinary diagnosis and treatment.