艾滋病相关非霍奇金淋巴瘤的治疗研究进展<sup>★</sup>

doi:10.3969/j.issn.2095-1264.2022.05.02

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艾滋病相关非霍奇金淋巴瘤的治疗研究进展★
DOI:
                        10.3969/j.issn.2095-1264.2022.05.02
                    
作者:
                        
                        
                    
作者单位:1.昆明医科大学第二附属医院，云南 昆明，650101;2.云南省传染病专科医院，云南 昆明，650000
作者简介:周婧，女，硕士，研究方向：淋巴瘤的基础与临床研究。
通讯作者:周泽平，男，博士，博士生导师，研究方向：血液系统疾病。
中图分类号:R733.4
基金项目:★国家自然科学基金（81860031， 81260091）；云南省科技厅-昆明联合专项（2018FE001-233， 2018FE001-049）；云南省医学领军人才培养项目（L-2017005）；昆医创新团队（CXTD201615）；云南省内设研究机构项目（2016NS245）。

Research progress in the treatment of AIDS-related non-Hodgkin lymphoma^★

Author:

Affiliation:

1.The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, Yunnan, China;2.Yunnan Provincial Infectious Diseases Hospital, Kunming, 650000, Yunnan, China

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摘要:

非霍奇金淋巴瘤（NHL）是艾滋病相关恶性肿瘤疾病中最为常见的一种。联合抗逆转录病毒疗法（cART）可使HIV感染者获得免疫重建，提升对化疗的耐受能力，且多数患者可从中获益。艾滋病相关NHL具有高度异质性，临床表现多样，发病机制较为复杂，治疗困难。近年来，大量临床试验及前瞻性研究数据得以更新，分子学及肿瘤基因组学、免疫学等各类新技术研究不断深入，为艾滋病相关NHL的治疗提供了新思路。本文主要对其几个亚型在治疗策略及新药物研究中的进展作一综述。

Abstract:

Non-Hodgkin lymphoma (NHL) is one of the most common AIDS-related malignancies. The combined retrovirus therapy (cART) could improve immune reconstitution and chemotherapy tolerance in HIV-infected patients, and most patients can benefit from it. Due to its high heterogeneity, diverse clinical manifestations and complex pathogenesis, AIDS-related NHL is difficult to treat. In recent years, a large number of clinical trials and prospective studies have been updated, and new technologies such as molecular, tumor genomics and immunology have been further studied, all of which provide new ideas for the treatment of AIDS-related NHL. This article reviewed the progress of several subtypes of AIDS-related NHL in the research of therapeutic strategies and new drugs.